February 11, 2004

Life and death, GMO-style

Another interesting trend in genetic engineering is using the technology for targeted assassination, wiping out cells or perhaps even whole species. (And I promise this will be more interesting than yesterday's overly-detailed post.)

Here is some of the bigger stuff that's afoot in this field:

  • Scientists at Duke created a GM virus that attacks and kills brain tumors in mice and "nonhuman primates" within 6 hours. How did they do it? They used the polio virus and changed its internal ribosomal entry site (IRES), which is a sort of key that a virus uses to infiltrate a cell, take control of it, and force it to create more viruses, killing the poor cell. They switched the polio virus' IRES with the virus that causes the common cold, the rhinovirus, which does not affect the brain. The engineered virus still attacks the cancer cells. I don't know the biology so well, but this sounds amazing to me, though I am a little wary of whether the virus may attack a few normal brain cells.

  • Another side of the genetically-engineered virus story is that scientists can create killer viruses. A team at St Louis University spawned a beefed-up mousepox virus that was immune to individual vaccines and killed all mice it infected. They also found a two-drug mixture that protected against the virus. This research follows a similar study from Australia three years ago where researchers accidentally made a mouse-killing super virus but did not find a cure. The researchers say bad guys can make these killer viruses so we should make them first and figure out how to protect against them. Mousepox is very similar to smallpox, "which is believed to have killed more people than all wars and epidemics combined."


  • Other scientists are working on killing out entire species, like the mosquitoes that carry malaria and dengue fever. This is fairly far off, but they're working on making recessive, especially selfish, "knock-out" genes that propagate better than your conventional Mendelian-propagating gene. The gene would spread through the entire population and when any individual has two knock-outs it dies. Not only is it unclear whether this will work technically, it also raises concerns about wiping out species and the potential that knock-out genes could end up in places we don't want 'em.

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